“DO NOT EAT TOO MUCH OF SWEET” Haven’t we been fed up with hearing these kinds of verses. especially our sweet-toothed friends out there. Well, this is one of the many factors explaining it.
A recent study done by Dr Hasan Zaki, a UT Southwestern assistant professor of pathology, found that intake of excess dietary sugar is one of the main causes of diseases such as IBD. Inflammatory Bowel Disorder or IBD is characterized by both ulcerative colitis and Crohn’s disease. Colitis can cause persistent diarrhoea, abdominal pain, and rectal bleeding. The number of American adults suffering from IBD (which includes Crohn’s disease) jumped from 2 million in 1999 to 3 million in 2015, according to the Centers for Disease Control and Prevention. Also, colitis is beginning to show up in children, who historically did not suffer from it.
As the most possible risk factor is a Western-style diet — high in fat, sugar, and animal protein. He tried to develop an experiment… and here’s what happened.
UT Southwestern researchers fed mice a solution of water with a 10 percent concentration of various dietary sugars — glucose, fructose, and sucrose — for seven days. They found that mice that were either genetically predisposed to develop colitis, or those given a chemical that induces colitis, developed more severe symptoms if they were first given sugar.
The researchers then used gene-sequencing techniques to identify the types and prevalence of bacteria found in the large intestines of mice before and after receiving their sugar regimen. After being given sugar treatments for seven days, that fed sucrose, fructose, and — especially — glucose showed significant changes in the microbial population inside the gut, according to the study.
Bacteria known to produce mucus-degrading enzymes, such as Akkermansia, were found in greater numbers, while some other types of bugs considered good bacteria and commonly found in the gut, such as Lactobacillus, became less abundant. The researchers saw evidence of a thinning of the mucus layer that protects the lining of the large intestine as well as signs of infection by other bacteria. “The mucus layer protects intestinal mucosal tissue from infiltration of gut microbiota,” the study explains.
“Higher abundance of mucus-degrading bacteria, including Akkermansia muciniphila and Bacteroides fragilis, in glucose-treated mice is, therefore, a potential risk for the intestinal mucus barrier. “Due to the erosion of the mucus layer, gut bacteria were in close proximity with the epithelial layer of the large intestine in glucose-treated mice,” the study continues. “Breaching of the epithelial barrier is the key initiating event of intestinal inflammation.”
Although glucose had the greatest effect, “all three simple sugars profoundly altered the composition of gut microbiota,” the study reports. Previous studies have shown that the gut microbiota of both humans and mice can change rapidly with a change in diet. “Our study clearly shows that you have to mind your food,” says Zaki. After finding changes in the gut microbiota in sugar-fed mice, the researchers fed feces from the sugar-treated mice to other mice. Those mice developed worse colitis, suggesting that glucose-induced susceptibility to colitis can be transmitted along with the destructive intestinal microbiota from affected animals.
They are doing more research on how high dietary intake has lead to the increase of other inflammatory diseases such as obesity, fatty liver disease, and neurodegenerative diseases like Alzheimer’s.
Stay tuned to know more about such exciting theories…
Reference: UT Southwestern Medical Center:-
“High-sugar diet can damage the gut, intensifying risk for colitis”
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